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Title of Journal: Fish Physiol Biochem

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Abbravation: Fish Physiology and Biochemistry

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Publisher

Springer Netherlands

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DOI

10.1016/0148-9062(94)92549-6

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ISSN

1573-5168

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Identification of Emphasis Type="Italic"HIF/Emp

Authors: Shasha Liu Kecheng Zhu Nan Chen Weimin Wang Huanling Wang
Publish Date: 2013/02/08
Volume: 39, Issue: 5, Pages: 1153-1163
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Abstract

The ubiquitously expressed hypoxiainducible factor1α HIF1α acts as a key transcription factor in regulating metabolism development cellular survival proliferation and pathology under hypoxia condition Compared to mammals fish are more vulnerable to hypoxia stress and contamination however the regulation of HIF1α in fish remains obscure In this study zebrafish HIF1α promoter was cloned and found to possess a CpG island located at −97 to +403 but the canonical TATAbox was absent Aligning 240bp HIF1α proximal promoter region of zebrafish with other vertebrates showed more than 82  identity with cyprinid fishes Further luciferase analysis suggested that the minimal core promoter might locate at −134 to +97 and several putative transcription factor binding sites were found in this region by bioinformatic analysis Moreover it was shown that the zebrafish HIF1α mRNA was significantly activated by 10 μg/mL lipopolysaccharide LPS under hypoxia condition and peaked at 8 h after treatment suggesting LPS and hypoxiaregulated zebrafish HIF1α transcriptional activity in a synergistic pattern This synergistic effect was closely related to the living environment of fish indicating that this mechanism would be more conducive to fish survival


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  1. Dynamic methylation pattern of cyp19a1a core promoter during zebrafish ovarian folliculogenesis
  2. Identification of low-molecular-weight vitellogenin 1 (Vg1)-like proteins as nucleotide excision repair (NER) factors in developing zebrafish ( Danio rerio ) using a transcription-based DNA repair assay
  3. Observation of the middle intestinal tight junction structure, cloning and studying tissue distribution of the four Claudin genes of the grass carp ( Ctenopharyngodon idellus)
  4. Spatial learning-induced egr - 1 expression in telencephalon of gold fish Carassius auratus
  5. Cloning and characterization of the HSP90 beta gene from Tanichthys albonubes Lin (Cyprinidae): effect of copper and cadmium exposure
  6. Protein and energy utilization and the requirements for maintenance in juvenile mulloway ( Argyrosomus japonicus )
  7. Evoked potentials in the Atlantic cod following putatively innocuous and putatively noxious electrical stimulation: a minimally invasive approach
  8. Nutritional evaluation of phosphorylated pumpkin seed ( Cucurbita moschata ) protein concentrate in silver catfish Rhamdia quelen (Quoy and Gaimard, 1824)
  9. Antioxidative role of selenium against the toxic effect of heavy metals (Cd +2 , Cr +3 ) on liver of rainbow trout ( Oncorhynchus mykiss Walbaum 1792)
  10. Molecular cloning, characterization, and expression analysis of luteinizing hormone receptor gene in turbot ( Scophthalmus maximus )
  11. Identification of Stress Sensitive Genes in Hyperthermic Atlantic Salmon ( Salmo salar ) Embryos by RAP-PCR
  12. Nitrogenous and phosphorus excretions in juvenile silver catfish ( Rhamdia quelen ) exposed to different water hardness, humic acid, and pH levels
  13. Fish condensate as effective replacer of fish meal protein in diet for striped snakehead, Channa striata (Bloch)
  14. The effects of cadmium and copper on embryonic and larval development of ide Leuciscus idus L.
  15. Induction of phase II enzymes and hsp70 genes by copper sulfate through the electrophile-responsive element ( EpRE ): insights obtained from a transgenic zebrafish model carrying an orthologous EpRE sequence of mammalian origin
  16. Substrate specificity of brain acetylcholinesterase and its sensitivity to carbamate insecticides in Carassius auratus
  17. Unmethylated CpG oligodeoxynucleotides activate head kidney leukocytes of Atlantic cod, Gadus morhua
  18. Peptide mapping of polymorphic myosin heavy chain isoforms in different muscle types of some freshwater teleosts
  19. Universal antisera for immunocytochemical identification of two different gonadotrophs in acanthopterygian fishes
  20. The isoelectric point, a key to understanding a variety of biochemical problems: a minireview
  21. Adaptive alterations on gill Na + , K + -ATPase activity and mitochondrion-rich cells of juvenile Acipenser sinensis acclimated to brackish water
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  23. Stress-induced inhibition of recruitment of ovarian follicles for vitellogenic growth and interruption of spawning cycle in the fish Oreochromis mossambicus
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  25. Spectral sensitivity of juvenile chub mackerel ( Scomber japonicus ) in visible and ultraviolet light
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