Authors: DONG SUP LEE SU JIN KIM EUN BI KWON CHEOL WHEE PARK SU MIN JUN BUMKYOO CHOI SAE WOONG KIM
Publish Date: 2013/12/21
Volume: 36, Issue: 6, Pages: 1127-1132
Abstract
Implantable devices are often composed of or coated with different biologically compatible materials based on their requirements Selecting a surface material for an implantable device is not an easy task and it is necessary to compare the biocompatibilities of the available surface materials In this study we perform a comparison of the in vivo biocompatibilities of polydimethylsiloxane PDMS and paraxylyene polymer paryleneC as they are considered to be candidates for a coating material for implantable microelectronic devices For in vivo biocompatibility testing fifty four male SpragueDawley rats were used for testing and they were divided into three groups PDMS paryleneC and a positive control At one four and twelve weeks after implantation of the test object the density of inflammatory cells and the granulation layer thickness were recorded for each group and compared with other groups using visible light and fluorescence microscopy The thickness of the granulation layer tended to decrease over time for all of the experimental groups whereas the granulation layer thickness remained constant in the positive control group The thinnest capsular layer was observed for the paryleneC group and fewest inflammatory cells were observed in this group during the entire experimental period Macrophage infiltration was minimal even at one week and was not observed thereafter The paryleneC group showed better biocompatibility than the PDMS groups both for acute and chronic implantation Thus paryleneC is the best candidate of the tested materials for applications involving permanent implantable microdevices
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