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Title of Journal: Drugs

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Abbravation: Drugs

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Springer International Publishing

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DOI

10.1007/bf00925971

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1179-1950

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Ivabradine Cardioprotection By and Beyond Heart R

Authors: Gerd Heusch Petra Kleinbongard
Publish Date: 2016/04/04
Volume: 76, Issue: 7, Pages: 733-740
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Abstract

Ivabradine inhibits hyperpolarizationactivated cyclic nucleotidegated channels in the sinus node thereby reducing heart rate and heart rate reduction improves regional myocardial blood flow and contractile function in ischemic myocardium Accordingly ivabradine reduces anginal symptoms in patients with stable coronary artery disease but does not improve their clinical outcome Heart rate reduction with ivabradine in patients with symptomatic heart failure reduces symptoms attenuates remodeling and improves clinical outcome In pigs and mice ivabradine reduces infarct size from myocardial ischemia/reperfusion even when heart rate reduction is abrogated by atrial pacing Improved viability is also observed in isolated ventricular cardiomyocytes subjected to simulated ischemia/reperfusion These beneficial effects are attributed to reduced reactive oxygen species formation from the mitochondria There is also evidence for a heart rateindependent benefit from ivabradine in the vasculature of mice and humans and in left ventricular contractile function of pigs Finally in mice ivabradine also has antiaging potential

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