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Title of Journal: JAMA

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Abbravation: JAMA

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American Medical Association

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DOI

10.1002/ett.2638

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0098-7484

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HTLVIII Antibodies After Immune Globulin

Authors: Dennis Piszkiewicz
Publish Date: 1987/01/16
Volume: 257, Issue: 3, Pages: 316-316
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Abstract

To the Editor—  In their recent letter Wolfe et al1 presented an analysis of the potential of a transient falsepositive reaction on an enzymelinked immunosorbent assay for antibody to human Tcell lymphotropic virus type III HTLVIII in recipients of immune globulin IG made from unscreened source material Their analysis was limited to the case of intramuscular administration of a 5mL dose of IG to US military personnelTwo factors not included in the case analyzed by Wolfe et al can greatly increase the chance of observing a transient falsepositive in the HTLVIII antibody test The standard dose in the case presented by these authors calculated on the basis of their assumptions is 10 mg/kg Intravenous IV IG therapy is often given at a dosage of 400 mg/kg Consequently a recipient of IV IG may have a serum titer of passively received antibodies that is 40 times greater than that

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References

citation title=Safety of immunoglobulin preparation containing antiHTLVIII citation author=Tedder RS Uttley A CheingsongPopov RLancet citation year=1985 citation volume=1 citation pages=815

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