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Title of Journal: JAMA

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Abbravation: JAMA

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American Medical Association

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DOI

10.1016/0022-5088(85)90347-9

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0098-7484

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Tubal Ligation Hysterectomy and Risk of Ovarian

Authors: AnnLouise S Silver
Publish Date: 1994/04/27
Volume: 271, Issue: 16, Pages: 1235-1235
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Abstract

To the Editor  —Dr Hankinson and colleagues1 report a strong inverse association between tubal ligation and ovarian cancer in which tubal ligation reduced the risk of ovarian cancer to about onethird that of the control group simple hysterectomy was almost as effective How can one explain this The authors speculate that blood supply to the ovaries might be affected Also they mention that oral contraceptives also have been shown to reduce the risk of ovarian cancer2 Meanwhile they report on the intriguing data implicating talc as a causative agent35 but do not highlight this evidence of the flow of carcinogenic and other agents from perineum to ovariesIs it possible that tubal ligation prevents ovarian cancer simply by limiting the upward flow of yettobeidentified toxins Are contraceptive foams and gels to be implicated Were these materials studied in the Nurses Health Study Tubal ligation hysterectomy and oral


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References

citation title=Talc in normal and malignant ovarian tissue citation author=Henderson WJ Hamilton TC Griffiths KLancet citation year=1979 citation volume=1 citation pages=499


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