Hepatitis B Vaccine Responsiveness in Connecticut

Authors: Aaron J Roome Stephen J Walsh Matthew L Cartter James L Hadler

Publish Date: 1993/12/22

Volume: 270, Issue: 24, Pages: 2931-2934

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Abstract

Results  —All subjects in the study had been vaccinated using Recombivax HB a recombinant hepatitis B vaccine Of 528 individuals 119 were found to have no or inadequate levels of antibody The frequency of inadequate level of antibody increased significantly relative to age from 28 among those younger than 30 years to 421 among those older than 60 years P0001 Smoking odds ratio OR 36 95 confidence interval CI 20 to 64 extreme obesity OR 133 95 CI 38 to 491 and increasing time interval since completing the vaccine series P01 were also associated with inadequate levels of antibody These findings were confirmed by multivariate analysis using logistic regressionConclusions  —Routine immunization of public safety personnel should include selective use of postvaccine testing Postvaccination testing optimally should be performed in the 30 to 90day interval after the last vaccine dose New vaccination strategies are needed to improve response rates in persons with predictably poor response to hepatitis B vaccineJAMA 199327029312934

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