Authors: Cynthia A Molloy Ardythe L Morrow Jareen MeinzenDerr Geraldine Dawson Raphael Bernier Michelle Dunn Susan L Hyman William M McMahon Julie GoudieNice Susan Hepburn Nancy Minshew Sally Rogers Marian Sigman M Anne Spence Helen TagerFlusberg Fred R Volkmar Catherine Lord
Publish Date: 2006/04/06
Volume: 36, Issue: 3, Pages: 317-
Abstract
A multicenter study of 308 children with Autism Spectrum Disorder ASD was conducted through the Collaborative Programs of Excellence in Autism CPEA sponsored by the National Institute of Child Health and Human Development to compare the family history of autoimmune disorders in children with ASD with and without a history of regression A history of regression was determined from the results of the Autism Diagnostic InterviewRevised ADIR Family history of autoimmune disorders was obtained by telephone interview Regression was significantly associated with a family history of autoimmune disorders adjusted OR=189 95 CI 117 310 The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease adjusted OR=209 95 CI 128 341We are grateful to the patients and families at all the CPEA sites who participated in this research We thank Dr Mekibib Altaye for his critical review of the statistical analyses We also thank Dr Thayne Sweeten for his thoughtful reading and comments on the manuscript and Deb Anderson for her assistance in data management
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