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Title of Journal: J Autism Dev Disord

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Abbravation: Journal of Autism and Developmental Disorders

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Springer US

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DOI

10.1016/0030-3992(92)90105-b

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ISSN

1573-3432

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OpenLabel Memantine in Fragile X Syndrome

Authors: Craig A Erickson Jennifer E Mullett Christopher J McDougle
Publish Date: 2009/07/16
Volume: 39, Issue: 12, Pages: 1629-1635
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Abstract

Glutamatergic dysfunction is implicated in the pathophysiology of fragile X syndrome FXS The purpose of this pilot study was to examine the effectiveness and tolerability of memantine for a number of target symptoms associated with FXS Medical records describing openlabel treatment with memantine in 6 patients with FXS and a comorbid diagnosis of PDD were reviewed Six patients received memantine over a mean 347 weeks of treatment Four of 6 67 patients showed global clinical benefit on ratings with the CGII Symptom specific rating scales however showed no statistically significant improvement Two patient developed treatmentlimiting irritability on memantine Memantine was modestly effective in several patients with FXS Further systematic study is warrantedThis work is supported in part by The Division of Disability Rehabilitative Services Indiana Family and Social Services Administration Drs Erickson McDougle National Institute of Health grant K12 UL1 RR025761 Indiana University Clinical and Translational Sciences Institute Career Development Award Dr Erickson and NIMH grant R01 MH072964 Dr McDougle

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Other Papers In This Journal:
  1. Hospitalizations of Children with Autism Increased from 1999 to 2009
  2. Evaluating Posed and Evoked Facial Expressions of Emotion from Adults with Autism Spectrum Disorder
  3. Profound Expressive Language Impairment in Low Functioning Children with Autism: An Investigation of Syntactic Awareness Using a Computerised Learning Task
  4. Brief Report: “Quick and (not so) Dirty” Assessment of Change in Autism: Cross-Cultural Reliability of the Developmental Disabilities CGAS and the OSU Autism CGI
  5. The Social Orienting Continuum and Response Scale (SOC-RS): A Dimensional Measure for Preschool-aged Children
  6. Familial Autoimmune Thyroid Disease as a Risk Factor for Regression in Children with Autism Spectrum Disorder: A CPEA Study
  7. Adaptive Functioning in Autism Spectrum Disorder During the Transition to Adulthood
  8. Scott Bellini, Building Social Relationships: A Systematic Approach to Teaching Social Interaction Skills to Children and Adolescents with Autism Spectrum Disorders and Other Social Difficulties (Textbook Edition, 1st ed.)
  9. An Effective Neurofeedback Intervention to Improve Social Interactions in Children with Autism Spectrum Disorder
  10. Evidence-Based Behavioral Interventions for Repetitive Behaviors in Autism
  11. O. Ivar Lovaas: Pioneer of Applied Behavior Analysis and Intervention for Children with Autism
  12. Global–Local Visual Processing in High Functioning Children with Autism: Structural vs. Implicit Task Biases
  13. Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder
  14. Anxiety and Sensory Over-Responsivity in Toddlers with Autism Spectrum Disorders: Bidirectional Effects Across Time
  15. Offit Paul: Autism’s False Prophets: Bad Science, Risky Medicine, and the Search for a Cure
  16. Epidemiology of Injury-Related Emergency Department Visits in the US Among Youth with Autism Spectrum Disorder
  17. Brief Report: Are Autistic-Behaviors in Children Related to Prenatal Vitamin Use and Maternal Whole Blood Folate Concentrations?
  18. Do Researchers Evaluate Psychosocial Interventions for Autism from the Perspective of the Three Dominant Cognitive Autism Theories?
  19. Daytime Secretion of Salivary Cortisol and Alpha-Amylase in Preschool-Aged Children with Autism and Typically Developing Children
  20. Factor Analysis of the Childhood Autism Rating Scale in a Sample of Two Year Olds with an Autism Spectrum Disorder
  21. Knowledge and Use of Intervention Practices by Community-Based Early Intervention Service Providers
  22. Breif Report: Sensory Abnormalities as Distinguishing Symptoms of Autism Spectrum Disorders in Young Children
  23. C. Avraham-Krehwinkel and D. Aldridge, A Non-Violent Resistance Approach with Children in Distress: A Guidebook for Parents and Professionals
  24. Evidence-Based Social Skills Training for Adolescents with Autism Spectrum Disorders: The UCLA PEERS Program
  25. The Collateral Effects of Joint Attention Training on Social Initiations, Positive Affect, Imitation, and Spontaneous Speech for Young Children with Autism
  26. The Effectiveness of Parent–Child Interaction Therapy for Families of Children on the Autism Spectrum
  27. Comparative Analysis of Three Screening Instruments for Autism Spectrum Disorder in Toddlers at High Risk
  28. JADD Announcements for September 2009
  29. Brief Report: Autism Spectrum Disorder and Substance Use Disorder: A Review and Case Study
  30. Effects of Cognitive Behavioral Therapy on Daily Living Skills in Children with High-Functioning Autism and Concurrent Anxiety Disorders
  31. Prenatal and Neonatal Thyroid Stimulating Hormone Levels and Autism Spectrum Disorders
  32. Metabolic Imbalance Associated with Methylation Dysregulation and Oxidative Damage in Children with Autism
  33. Employment and Vocational Skills Among Individuals with Autism Spectrum Disorder: Predictors, Impact, and Interventions
  34. Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism
  35. Brief Report: The ADOS Calibrated Severity Score Best Measures Autism Diagnostic Symptom Severity in Pre-School Children
  36. Social Skills Training for Young Adults with High-Functioning Autism Spectrum Disorders: A Randomized Controlled Pilot Study
  37. Differentiating between Autism Spectrum Disorders and Other Developmental Disabilities in Children Who Failed a Screening Instrument for ASD
  38. Discriminant and Convergent Validity of the Anxiety Construct in Children with Autism Spectrum Disorders
  39. Using Discrete Trial Training to Identify Specific Learning Impairments in Boys with Fragile X Syndrome
  40. Maternal Early Life Factors Associated with Hormone Levels and the Risk of Having a Child with an Autism Spectrum Disorder in the Nurses Health Study II
  41. A Review of the Use of Touch-Screen Mobile Devices by People with Developmental Disabilities
  42. Social and Non-social Hazard Response in Drivers with Autism Spectrum Disorder
  43. Using Carey Temperament Scales to Assess Behavioral Style in Children with Autism Spectrum Disorders
  44. Brief Report: Learning Via the Electronic Interactive Whiteboard for Two Students with Autism and a Student with Moderate Intellectual Disability
  45. Maternal Smoking and Autism Spectrum Disorder: A Meta-analysis
  46. Brief Report: Adaptive Behavior and Cognitive Skills for Toddlers on the Autism Spectrum
  47. Response Times of Children and Adolescents with Asperger Syndrome on an ‘Advanced’ Test of Theory of Mind
  48. Group Intervention to Promote Social Skills in School-age Children with Pervasive Developmental Disorders: Reconsidering Efficacy
  49. Prevalence and Correlates of Screen-Based Media Use Among Youths with Autism Spectrum Disorders
  50. Brief Report: Pragmatic Language in Autism Spectrum Disorder: Relationships to Measures of Ability and Disability
  51. An Electrophysiological Investigation of Interhemispheric Transfer Time in Children and Adolescents with High-Functioning Autism Spectrum Disorders
  52. Diary Reports of Concerns in Mothers of Infant Siblings of Children with Autism Across the First Year of Life
  53. The Social Behavioral Phenotype in Boys and Girls with an Extra X Chromosome (Klinefelter Syndrome and Trisomy X): A Comparison with Autism Spectrum Disorder
  54. Brief Report: Influence of Physical Activity on Sleep Quality in Children with Autism
  55. Reliability and Validity of Parent- and Child-Rated Anxiety Measures in Autism Spectrum Disorder
  56. Early Language Patterns of Toddlers on the Autism Spectrum Compared to Toddlers with Developmental Delay
  57. Explaining and Selecting Treatments for Autism: Parental Explanatory Models in Taiwan
  58. Brief Report: The Effects of Tomatis Sound Therapy on Language in Children with Autism
  59. Meg Grigal and Debra Hart: Think College
  60. Daily Couple Experiences and Parent Affect in Families of Children with Versus Without Autism
  61. In the Eye of the Beholder: Rapid Visual Perception of Real-Life Scenes by Young Adults with and Without ASD
  62. Brief Report: Effects of Sensory Sensitivity and Intolerance of Uncertainty on Anxiety in Mothers of Children with Autism Spectrum Disorder
  63. Network Approach to Autistic Traits: Group and Subgroup Analyses of ADOS Item Scores
  64. Residual Difficulties with Categorical Induction in Children with a History of Autism
  65. No Evidence of Emotional Dysregulation or Aversion to Mutual Gaze in Preschoolers with Autism Spectrum Disorder: An Eye-Tracking Pupillometry Study
  66. Gender in Voice Perception in Autism
  67. The Relationship Between Clinical Presentation and Unusual Sensory Interests in Autism Spectrum Disorders: A Preliminary Investigation
  68. Views on the Diagnostic Labels of Autism and Asperger’s Disorder and the Proposed Changes in the DSM
  69. Adaptive Profiles in Autism and Other Neurodevelopmental Disorders
  70. Mothers of Children with Developmental Disorders in the Bedouin Community in Israel: Family Functioning, Caregiver Burden, and Coping Abilities
  71. Scalar Inferences in Autism Spectrum Disorders
  72. Use of a Teacher Nomination Strategy to Screen for Autism Spectrum Disorders in General Education Classrooms: A Pilot Study
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