Authors: Sharon A Kidd Blythe A Corbett Douglas A Granger W Thomas Boyce Thomas F Anders Ira B Tager
Publish Date: 2012/04/04
Volume: 42, Issue: 12, Pages: 2648-2658
Abstract
We examined daytime salivary cortisol and salivary alphaamylase sAA secretion levels and variability in preschoolaged children with autism AUT and typically developing children TYP Fiftytwo subjects 26 AUT and 26 TYP were enrolled Salivary samples were obtained at waking midday and bedtime on two consecutive days at three phases baseline 3 months later 6 months later There were modest increases in waking cortisol and sAA levels in AUT relative to TYP but the increases were not statistically significant Important differences were observed in cortisol and sAA variability between AUT and TYP There was also a graded response among AUT by functional status—cortisol and sAA secretion levels were higher when IQ was lowerThe most heartfelt thank you goes to the families and their children who generously participated in the study We also would like to thank the research staff on the Sleep in Children with Autism Study Karen Tang Anny Wu Stephanie Sitnick Sara Waters and Shacunda Burton who graciously assisted with the families Melissa Amacher volunteered her time on data entry and other tasks We are grateful for the management of samples by Mary Curran at Salimetrics LLC and Alan Hubbard for statistical advice on causal methodology Some of the infrastructure support for the study was provided by NIMH RO1 MH068232 PI Thomas Anders and the MIND Institute This paper was prepared in part from the dissertation of the corresponding author
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