Authors: Vincent M Yau Marta Lutsky Cathleen K Yoshida Bill Lasley Martin Kharrazi Gayle Windham Nancy Gee Lisa A Croen
Publish Date: 2014/09/02
Volume: 45, Issue: 3, Pages: 719-730
Abstract
Thyroid hormones are critical for normal brain development This study examined autism spectrum disorders ASD and thyroid stimulating hormone TSH levels measured in midpregnancy maternal serum and infant blood after birth Three groups of children born in Orange County CA in 2000–2001were identified ASD n = 78 developmental delay n = 45 and general population controls GP n = 149 Samples were retrieved from prenatal and newborn screening specimen archives Adjusted logistic regression models showed inverse associations between ASD and log transformed TSH levels in maternal serum samples ASD vs GP OR 95 CI 033 012–091 Early Onset ASD vs GP 031 010–098 Results for thyroid levels in newborn blood samples were similar though not significant ASD vs GP 061 018–204Funding was provided by grants from the National Institute of Mental Health R01MH72565 L Croen PI the National Alliance for Autism Research 824/LC/012010040000 L Croen PI and the California TobaccoRelated Disease Research Program 8RT0115 M Kharrazi PI We thank Jack Collins Roxana Odouli and Tiffany Wong for project coordination Julie Ruedaflores for record review and abstraction Meredith Anderson and Daniel Najjar for assistance with data management and analysis and Steve Graham and Debbie Hildebrandt for record linkage and specimen retrieval
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