Authors: Brittany N Rosen Brian K Lee Nora L Lee Yunwen Yang Igor Burstyn
Publish Date: 2014/11/29
Volume: 45, Issue: 6, Pages: 1689-1698
Abstract
We conducted a metaanalysis of 15 studies on maternal prenatal smoking and ASD risk in offspring Using a randomeffects model we found no evidence of an association summary OR 102 95 CI 093–112 Stratifying by study design birth year type of healthcare system and adjustment for socioeconomic status or psychiatric history did not alter the findings There was evidence that ascertaining exposure at the time of birth produced a lower summary OR than when this information was gathered after birth There was no evidence of publication bias Nondifferential exposure misclassification was shown to have the potential for negligible influence on the results We found no evidence to support a measurable association between maternal prenatal smoking and ASD in offspring
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