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Title of Journal: Pathol Oncol Res

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Abbravation: Pathology & Oncology Research

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Springer Netherlands

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DOI

10.1002/hlca.19670500504

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1532-2807

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Expression and Clinical Significance of FAK and Sr

Authors: Nikolaos A Chatzizacharias Constantinos Giaginis Elisavet Gatzidou Gerasimos Tsourouflis Ioannis Sfiniadakis Paraskevi Alexandrou Stamatios E Theocharis
Publish Date: 2010/11/07
Volume: 17, Issue: 2, Pages: 277-285
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Abstract

Focal Adhesion Kinase FAK is a protein tyrosine kinase localised in the focal adhesions which upon activation interacts with Src another tyrosine kinase regulating several cellular signalling pathways Both enzymes have been implicated in malignant transformation and disease progression The aim of the present study was to evaluate the clinical significance of FAK and Src expression in cases of endometrial adenocarcinoma The total t and the activated phosphorylated p forms of FAK and Src proteins were assessed immunohistochemically in tumour specimens obtained from 43 endometrial adenocarcinoma patients and were statistically analyzed in relation to various clinicopathological parameters and tumour proliferative capacity reflected by Ki67 labelling index tFAK positivity was significantly correlated with FIGO disease stage p = 0031 and tFAK overexpression with patients’ age p = 0015 No statistically significant correlation was identified between tFAK staining intensity tSrc positivity overexpression or staining intensity and any of the clinicopathological parameters tested No significant correlation was found between neither the positivity nor the intensity of staining of either pFAk or pSrc with any of the parameters under study Nonetheless important but nonsignificant trends were identified between tFAK staining intensity tSrc positivity and overexpression and patients’ survival log rank p = 0122 p = 0090 and p = 0057 respectively Similarly pFAK and pSrc staining characteristics seemed to correlate even though nonsignificantly with patients’ survival log rank p = 0051 and p = 0070 for pFAK and pSrc expression respectively log rank p = 0134 and p = 0110 for pFAK and pSrc staining intensity respectively These results support an important potential role of FAKSrc signalling in endometrial malignant disease progress and render further research in this field a necessity

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