ClinicoPathological Particularities of the Shock

Authors: Judit Kovacs Simona Gurzu Janos Jung Janos Szederjesi SandaMaria Copotoiu Ruxandra Copotoiu Leonard Azamfirei

Publish Date: 2012/04/24

Volume: 18, Issue: 4, Pages: 977-981

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Abstract

Acute pancreatitis can develop in patients with shock due to the underlying diseases surgical interventions or because of severe hypoperfusion The aim of our work was to study the histological alterations of the pancreas in patients dying after cardiogenic hypovolemic or septic shock to demonstrate the presence and severity of pancreatic injury We performed a retrospective study which included patients who died and who were autopsied after different types of shock hospitalized between 2007–2009 in general and cardiac intensive care units We excluded the patients with known pancreatic diseases From 223 patients included in our study 39 presented necrotising hemorrhagic alteration of the pancreatic tissue There were no differences in histological and immunohistochemical findings between the different etiopathogenetic types of shock None of the patients had characteristic clinical signs for acute pancreatitis The digestive symptoms they presented could be related to the underlying disease or to postoperative state The common findings in these patients were prolonged and severe hypotension associated renal dysfunction leucocytosis hyperglycemia and hypocalcemia Pancreatitis can occur in patients with shock due to prolonged hypoperfusion of the pancreas It is difficult to diagnose it because clinical signs are altered due to severity of underlying disease or analgosedation commonly used in intensive care We therefore recommend in patients with shock to consider the possible development of ischemic pancreatitis for prompt and efficient treatmentThis paper is partially supported by the Sectoral Operational Programme Human Resources Development financed from the European Social Fund and by the Romanian Government under the contract number POSDRU/89/15/S/60782 and by CNCSISUEFISCSU project number PNII IDEI code 136/2008”

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