Authors: Yun Sol Jo Sang Yong Song Min Sung Kim Nam Jin Yoo Sug Hyung Lee
Publish Date: 2016/10/22
Volume: 23, Issue: 1, Pages: 221-222
Abstract
Nonsensemediated mRNA decay NMD is a surveillance pathway that reduces errors in gene expression by eliminating mRNA transcripts that contain premature stop codons 1 Without the NMD translation of such aberrant mRNAs could lead to deleterious gainoffunction or dominantnegative activity of the resulting proteins As for tumors suppressed NMD can either promote or inhibit tumors depending on the natures of NMDcandidate transcripts For example NMD shows a tumor suppressor activity in the cancers with truncated forms of BRCA1 2 By contrast it shows an oncogenic role in those with truncated forms of CDH1 3 In humans NMD depends on UPF1 and six other proteins SMG1 UPF2 UPF3 SMG6 SMG5 and SMG7 1 The SMG7 coordinates with UPF1 to degrade NMDcandidate transcripts 4 NMDinactivating mutation of UPF1 gene is common in pancreatic adenosquamous carcinoma 5 indicating that NMD inhibition by somatic mutations of NMD machinery could possibly
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