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Title of Journal: Pathol Oncol Res

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Abbravation: Pathology & Oncology Research

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Springer Netherlands

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DOI

10.1016/1011-1344(95)07185-7

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1532-2807

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The Expression of High Mobility Group Box 1 is Ass

Authors: Chen Chuangui Tang Peng Yu Zhentao
Publish Date: 2012/04/29
Volume: 18, Issue: 4, Pages: 1021-1027
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Abstract

The objective is to explore the expression of high mobility group box 1 HMGB1 in esophageal squamous cell carcinoma ESCC and its relationship with lymph node metastasis and the prognosis of patients as well as possible mechanism The expression of HMGB1 vascular endothelial growth factor C VEGFC and lymphatic vessel endothelial hyaluronan receptor 1 LYVE1 in ESCC tissues which were obtained from 72 patients who underwent radical esophagectomy was detected through immunohistochemistry firstly The correlations between HMGB1 and VEGFC and microlymphatic vessel density MLD and lymph node metastasis and the prognosis of patients were analyzed by statistic analysis The plasmid of small interference RNA siRNA targeting HMGB1 giving siHMGB1 was transfected into exponentially growing KYSE150 human esophageal squamous cancer cells and the expression of HMGB1 mRNA and protein was observed by Realtime PCR and Western Blot and the expression of VEGFC was examined by ELISA HMGB1 expressed highly in the nuclei and cytoplasm of carcinoma cells as well as the extracellular space in ESCC and was associated with lymph node metastasis MLD the expression of VEGFC TNM stage and the prognosis of patients P  005 or P  001 In vitro siHMGB1 inhibited the expression of HMGB1 mRNA and protein and the secretion of VEGFC in KYSE150 cells In ESCC HMGB1 expresses highly and affects the prognosis of patients through regulating the expression of VEGFC to promote lymphangiogenesis and lymph node metastasis and HMGB1 might serve as the marker of progression and potential target for antilymphangiogenesis therapy

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