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Title of Journal: Pathol Oncol Res

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Abbravation: Pathology & Oncology Research

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Springer Netherlands

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DOI

10.1016/0168-9002(90)90182-6

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1532-2807

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Autologous Dendritic Cell Based Adoptive Immunothe

Authors: János Hunyadi Csilla András Imre Szabó János Szántó Kornélia Szluha Sándor Sipka Péter Kovács Attila Kiss Gyula Szegedi István Altorjay Péter Sápy Péter AntalSzalmás László Tóth György Fazekas Éva Rajnavölgyi
Publish Date: 2013/10/28
Volume: 20, Issue: 2, Pages: 357-365
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Abstract

Dendritic cellbased active immunotherapies of cancer patients are aimed to provoke the proliferation and differentiation of tumorspecific CD4+ and CD8+ Tlymphocytes towards protective effector cells Isolation and in vitro differentiation of circulating blood monocytes has been established a reasonable platform for adoptively transferred DCbased immunotherapies In the present study the safety and tolerability of vaccination by autologous tumor cell lysates oncolysate or carcinoembriogenic antigen CEAloaded DCs in patients with colorectal cancer was investigated in a phase III trial The study included 12 patients with histologically confirmed colorectal cancer Dukes B2C stages Six of the patients received oncolysatepulsed whereas the other six received recombinant CEAloaded autologous DCs The potential of the tumor antigenloaded DCs to provoke the patient’s immune system was studied both in vivo and in vitro The clinical outcome of the therapy evaluated after 7 years revealed that none of the six patients treated with oncolysateloaded DCs showed relapse of colorectal cancer whereas three out of the six patients treated with CEAloaded DCs died because of tumor relapse Immunization with both the oncolysate and the CEAloaded autologous DCs induced measurable immune responses which could be detected in vivo by cutaneous reactions and in vitro by lymphocyte proliferation assay Our results show that vaccination by autologous DCs loaded with autologous oncolysates containing various tumor antigens represents a well tolerated therapeutic modality in patients with colorectal cancer without any detectable adverse effects Demonstration of the efficacy of such therapy needs further studies with increased number of patients

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