Authors: Yusen Zhu Min Liu Xiaojing Yun Dongmei Wang Yuhuan Bai Guizhi Zhang Bei Ji Changchun Jing
Publish Date: 2016/12/24
Volume: 23, Issue: 3, Pages: 657-663
Abstract
We aimed to review the therapeutic effects of neoadjuvant chemoradiotherapy NCRT chemotherapy NCT and radiotherapy NRT on patients with resectable Esophageal cancer EsC by comparison with surgery alone SA PubMed EMBASE and Cochrane were searched for eligible studies published up to March 2015 Cochrane reviews were used for quality assessment Eight primary outcomes were analyzed Risk ratios RRs/ hazard ratios HRs and corresponding 95 confidence intervals 95 CIs were calculated using the random or fixed effects model Heterogeneity was assessed using the Chisquarebased Q statistic and the I 2 test Publication bias was examined by the Begg’s funnel plot Totally 24 articles including 4718 EsC cases were eligible for this metaanalysis The quality of the literatures was relatively high Significant difference was found in fiveyear survival rate RR = 145 95 CI 117–179 P 001 between patients treated with NCT and SA while the eight enrolled primary outcomes were all statistically different between NCRT and SA and significant difference was identified in threeyear survival between NCRT and NCT RR = 135 95 CI 114–160 P 001 No obvious publication bias was observed NCRT and NCT provide an obvious benefit for EsC treatment over SA and NCRT possesses a clear advantage compared with NCT
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