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Title of Journal: Pathol Oncol Res

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Abbravation: Pathology & Oncology Research

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Springer Netherlands

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10.1007/bf01249872

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1532-2807

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Neuroendocrine Tumors of Extrahepatic Biliary Trac

Authors: Nickos Michalopoulos Theodossis S Papavramidis Georgia Karayannopoulou Ioannis Pliakos Spiros T Papavramidis Ioannis Kanellos
Publish Date: 2014/06/11
Volume: 20, Issue: 4, Pages: 765-775
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Abstract

Neuroendocrine tumors of the extrahepatic bile ducts EBNETs are very rare The aim of the present review is to elucidate the characteristics of EBNETs their treatment and prognosis An exhaustive systematic review of the literature was performed from 1959 uptodate One hundred articles describing 150 cases were collected Each article was carefully analyzed and a database was created The most common symptoms were jaundice 603  and pruritus 192  Cholelithiasis coexisted in 15 cases 192  Hormone and vasoactive peptide related symptoms were present in only 7 cases 9  The most frequent sites were found to be the common hepatic duct and the proximal common bile duct 192  Surgical management was considered the main treatment for EBNETs while excision of extrahepatic biliary tree 6282  with portal vein lymphadenectomy 436  was the most popular procedure EBNETs are extremely rare Their rarity makes their characterization particularly difficult Up to date the final diagnosis is made after surgery by pathology and immunohistochemistry findings The present analysis of the existing published cases elucidates many aspects of these tumours giving complete clinicopathological documentation

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