Authors: A Karakurt S Saraç S Dalkara
Publish Date: 2012/08/26
Volume: 75, Issue: 19-20, Pages: 1191-1197
Abstract
The direct enantiomeric resolution of racemic 21Himidazole1yl1naphthalene2ylethanol esters 1naphthalene2ylethanol esters and 11hydroxynaphthalene2yl21Himidazole1ylethanol on silicabased cellulose tris35dimethylphenylcarbamate Chiralcel OD column is described The separations were performed using mobile phases which consist of alcohol methanol ethanol or 2propanol/nhexane in various proportions The effect of structural features of the solutes along with the nature and concentration of alcohol in the mobile phase on the discrimination between the enantiomers was examined for different mobile phase compositions The results suggest that not only the structure and concentration of alcohol in the mobile phase but also the subtle structural differences in racemates can have a pronounced effect on enantiomeric separation and retention Baseline separations were obtained for 21Himidazole1yl1naphthalene2ylethanol esters carrying imidazole ring in addition to ester functional group in their structures The α values of the resolved enantiomers of 21Himidazole1yl1naphthalene2ylethanol esters were in the range of 149–162 while the R s values varied from 420 to 675 when methanol/nhexane 7030 v/v was used as mobile phase
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