Journal Title
Title of Journal: Chromatographia
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Abbravation: Chromatographia
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Publisher
Springer Berlin Heidelberg
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Authors: Li Cui Fengjuan Xu Jun Jiang E Sun Zhenhai Zhang Xudong Cheng Jing Wang Xiaobin Jia
Publish Date: 2014/07/11
Volume: 77, Issue: 17-18, Pages: 1223-1234
Abstract
Herba Epimedii Epimedium is a kind of tonic herb widely used in China Epimedin A is a major component of Herba Epimedii with bioactivities Analysis of the metabolic profile in vivo plays a pivotal role in understanding how traditional Chinese medicine works And the metabolites of epimedin A might influence the effects of Herba Epimedii Moreover the metabolic routes of epimedin A provide an important basis for safety evaluation Until now little has been known about the metabolism of epimedin A The current study was designed to characterize the metabolic pathways of epimedin A in vivo The metabolites in rat plasma bile feces and urine were identified by UPLC/Q–TOF–MS analysis A total of 27 metabolites from epimedin A were detected or tentatively identified The major metabolic processes were hydrolysis hydrogenation hydroxylation dehydrogenation demethylation and conjugation with glucuronic acid and different sugars The present study revealed the metabolic pathways of epimedin A in rat for the first time and epimedin A could undergo extensive phase I and phase II metabolism in rat These findings would provide an important basis for the further study and clinical application of epimedin A In addition the results of this work have shown the feasibility of the UPLC/Q–TOF–MS approach for rapid and reliable characterization of metabolites
Keywords:
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