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Title of Journal: Chromatographia

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Abbravation: Chromatographia

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Springer Berlin Heidelberg

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1612-1112

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Analysis of Metabolites of Anthraquinones by Human

Authors: Min Fan Chongsheng Peng Ying Peng Min Zhang Xiaobo Li
Publish Date: 2016/10/18
Volume: 79, Issue: 23-24, Pages: 1593-1604
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Abstract

This study aimed to investigate the metabolism of anthraquinones including chrysophanol 1 rhein 2 aloeemodin 3 emodin 4 sennoside A 5 and sennoside B 6 by mixed human fecal bacteria to clarify the relationship between their chemical structural characteristics and intestinal metabolism Six parent compounds were incubated with mixed human fecal bacteria in vitro to study the metabolic process A highly sensitive and specific ultraperformance liquid chromatographyquadrupole timeofflight highresolution tandem mass spectrometry UPLCQTOFHRMS/MS with MSE technology and MetaboLynx software has been developed to analyze the metabolites of anthraquinones With this method a total of ten metabolites were identified including 148trihydroxy3hydroxymethylanthraquinone M1 2methylrhein M2 7methylrhein M3 methylesterificated rhein M4 18dihydroxy3hydroxymethyl4methylanthraquinone M5 physcion M6 sennidin A M7 rhein M8 sennidin B M9 and rhein M10 six M1–M6 of which were first detected on the basis of the exact mass by mixed human fecal bacteria in this work The metabolism of anthraquinones occurred via hydroxylation oxidation methylation deglycosylation and esterification In particular the methylesterificated rhein M4 was first identified as one of the metabolites of rhein whose metabolic pathway esterification is also reported for the first time The presence of human fecal bacteria played a vital role in the metabolism of anthraquinones and the substitutional groups determined the different metabolic reactions for anthraquinones which will be useful for the investigation of the study of anthraquinones in vivo


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