Journal Title
Title of Journal: Chromatographia
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Abbravation: Chromatographia
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Publisher
Springer Berlin Heidelberg
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Authors: Sha Liu Cuiling Wang Shuai He Ligai Bai Haiyan Liu
Publish Date: 2016/02/12
Volume: 79, Issue: 7-8, Pages: 441-449
Abstract
A polyionic liquidglycidylmethacrylatecoethyleneglycol dimethacrylate monolithic column was prepared via in situ freeradical polymerisation and used as an online solidphase extraction column The obtained monolithic column was characterized by scanning electron microscopy Fourier transform infrared spectrometer nitrogen adsorption–desorption measurement and mercury intrusion porosimetry which showed a relatively uniform and porous structure During the online solidphase extraction–high performance liquid chromatography protocol nifedipine nitrendipine and felodipine were separated efficiently from human plasma using a methanol–water linear gradient at a flow rate of 10 mL min−1 The extraction efficiency for the targets was satisfactory with no matrix interference Under the optimized extraction conditions the linear regression coefficient was 09973 precisions for inter and intraday assays presented as relative standard deviations were less than 729 and the accuracy and recovery was in the range of 96–105 and 90–106 respectively As a result the polymerization monolithic column exhibited high selectivity and good permeability and it was feasible to be used as an online SPE column Meanwhile validation assays also demonstrated acceptable sensitivity and precision for simultaneous quantitative screening of nifedipine nitrendipine and felodipine in human plasma
Keywords:
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