Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Int J Legal Med

Search In Journal Title:

Abbravation: International Journal of Legal Medicine

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1007/s12285-008-0028-3

Search In DOI:

ISSN

1437-1596

Search In ISSN:
Search In Title Of Papers:

Using bone marrow matrix to analyze meprobamate fo

Authors: F Bévalot M P Gustin N Cartiser Y Gaillard C Le Meur L Fanton J Guitton D Malicier
Publish Date: 2013/02/12
Volume: 127, Issue: 5, Pages: 915-921
PDF Link

Abstract

Bone marrow BM analysis is of forensic interest for postmortem toxicological investigations where blood samples are unavailable or unusable Due to the lack of studies it remains difficult to interpret concentrations of xenobiotics measured in this matrix Based on a statistical approach published previously to interpret meprobamate concentrations in bile and vitreous humor we propose here a diagnostic test for interpretation of BM meprobamate concentrations from analysis of 99 sets of autopsy data The mean age was 48 years range 18–80 years one unknown for males and 50 years range 19–80 years one unknown for females with a male/female ratio at 0768 A BM concentration threshold of 113 μg/g was found to be statistically equivalent to that of a blood meprobamate concentration threshold of 50 μg/ml in distinguishing overdose from therapeutic use The intrinsic qualities of this diagnostic test were good with sensitivity of 082 and specificity of 092 Compared to previous tests published with the same objective on vitreous humor and bile this study shows that BM is a useful alternative matrix to reveal meprobamate overdose when blood vitreous humor and bile are not available or unusable

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Microwave Digestion—Vacuum Filtration-Automated Scanning Electron Microscopy as a sensitive method for forensic diatom test
  2. Identification of human DNA in forensic evidence by loop-mediated isothermal amplification combined with a colorimetric gold nanoparticle hybridization probe
  3. The new influenza A (H1N1/09): symptoms, diagnostics, and autopsy results
  4. Analysis of 21 X-chromosomal STRs in an Algerian population sample
  5. Response of forest soil euglyphid testate amoebae (Rhizaria: Cercozoa) to pig cadavers assessed by high-throughput sequencing
  6. Molecular pathology of pulmonary edema after injury in forensic autopsy cases
  7. High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS
  8. Identification of forensically important Sarcophaga species (Diptera: Sarcophagidae) using the mitochondrial COI gene
  9. About the letter “Comments on the article, “Software for Y-Haplogroup Predictions, a Word of Caution”
  10. STR data for 15 autosomal STR markers from Paraná (Southern Brazil)
  11. Seventeen Y-chromosomal short tandem repeat haplotypes in seven groups of population living in Taiwan
  12. Exclusion probabilities and likelihood ratios with applications to mixtures
  13. A very long ACTBP2 (SE33) allele
  14. An extraordinary case of an intracranial foreign body after a gunshot to the head
  15. Smart drugs: green shuttle or real drug?
  16. The use of post-mortem computed tomography in the investigation of intentional neonatal upper airway obstruction: an illustrated case
  17. Pseudomonas aeruginosa septicemia causes death following liposuction with allogenic fat transfer and gluteal augmentation
  18. Y chromosome interstitial deletion induced Y-STR allele dropout in AMELY-negative individuals
  19. Crossbow homicides
  20. A validation study of the Nucleix DSI-Semen kit—a methylation-based assay for semen identification
  21. Development of a quantitative validation method for forensic investigation of human spermatozoa using a commercial fluorescence staining kit (SPERM HY-LITER™ Express)
  22. Postmortem magnetic resonance imaging of the heart ex situ: development of technical protocols
  23. Age-related DNA methylation changes for forensic age-prediction
  24. When backyard fun turns to trauma: risk assessment of blunt ballistic impact trauma due to potato cannons
  25. Which is the preferred image modality for paediatricians when assessing photographs of bruises in children?
  26. Diagnosis of aluminum phosphide poisoning using a new analytical approach: forensic application to a lethal intoxication
  27. Skin analysis following dermal exposure to kerosene in rats: the effects of postmortem exposure and fire
  28. Accuracy of scoring of the epiphyses at the knee joint (SKJ) for assessing legal adult age of 18 years
  29. Genetic variation study of 12 X chromosomal STR in central Thailand population
  30. Alagille syndrome case report: implications for forensic pathology and anthropology
  31. Application of six IrisPlex SNPs and comparison of two eye color prediction systems in diverse Eurasia populations
  32. Forensic characteristics and phylogenetic analyses of the Chinese Yi population via 19 X-chromosomal STR loci
  33. Differential gene expression during metamorphosis: a promising approach for age estimation of forensically important Calliphora vicina pupae (Diptera: Calliphoridae)
Search Result: