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Title of Journal: Int J Legal Med

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Abbravation: International Journal of Legal Medicine

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Springer Berlin Heidelberg

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DOI

10.1007/bf02917059

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1437-1596

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Highresolution mass spectrometric determination o

Authors: Kei Zaitsu Hiroshi Nakayama Mayumi Yamanaka Kazuaki Hisatsune Kentaro Taki Tomomi Asano Tooru Kamata Munehiro Katagai Yumi Hayashi Maiko Kusano Hitoshi Tsuchihashi Akira Ishii
Publish Date: 2015/09/08
Volume: 129, Issue: 6, Pages: 1233-1245
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Abstract

Highresolution mass spectrometry and accurate mass measurement by liquid chromatography/quadrupoletime of flight mass spectrometry LC/QTOFMS was applied to postmortem plasma and urine specimens from an autopsy of a fatal case involving synthetic cannabinoid use resulting in the detection of three synthetic cannabinoids MAM2201 AM1220 and AM2232 We searched for their metabolites existing in postmortem plasma or urine by LC/QTOFMS and were able to detect Ndealkylated metabolites defluorinated and further oxidized metabolites of MAM2201 and some hydroxylated metabolites Postmortem plasma concentrations of the parent drugs Ndealkylated metabolites and fluorinated and further oxidized metabolites of MAM2201 were measured and quantitation results revealed site differences between heart and femoral postmortem plasma concentrations of parent drugs and some metabolites suggesting postmortem redistribution of the synthetic cannabinoids and their metabolites Quantitation results suggest that defluorination is a major metabolic pathway for MAM2201 and Ndealkylation is a common but minor pathway for the naphthoylindoletype synthetic cannabinoids in human

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