Authors: Yi Wang Wenli Cheng Yong Wang Jingpin Peng Jie Yuan Li Chen Lin Pan Hong Li Jian Guo
Publish Date: 2015/03/17
Volume: 21, Issue: 5, Pages: 339-345
Abstract
Ninetysix patients with severe carotid stenosis were enrolled in the study and were classified into a QQG group n=48 and a control group n=48 randomly using consecutively numbered envelopes The patients in the QQG group were given QQG and Western medicine those in the control group were given Western medicine merely the course of treatment was 16 weeks All patients went through endarterectomy after treatment Plaques were subjected to the analysis of CD3 CD68 soluble intercellular adhesion molecule 1 ICAM1 matrix metalloprotease9 MMP9 CD40L tenascinC and collagen content lipid content by immunohistochemistry or polarized light analysisBy the end of experiment the expressions of CD3 CD68 ICAM1 MMP9 CD40L and tenascinC on the plaques were statistically significant lower in the QQG group compared with the control groupP001 The lipid content of the plaque was also significantly lower in the QQG group compared with the control group P001 The interstitial collagen in the tissue sections of the plaques was also significantly higher in the QQG group in comparison with the control group P001
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