Authors: ChienYing Lee HungChe Shih MinChien Yu MingYung Lee YaLan Chang YaYun Lai YiChing Lee YuHsiang Kuan ChunChe Lin
Publish Date: 2016/10/19
Volume: 23, Issue: 3, Pages: 176-182
Abstract
This is a 4week randomly assigned parallelgroup doubledblind and placebocontrolled study Fifty patients with a positive H pylori infection urea breath test △UBT result 10 and without ulcer symptoms were randomized into a treatment group and a placebo group by a computer generated allocation sheet with 11 These subjects took one capsule of probiotics or placebo twice daily The primary measurement was the change in △UBT valuesThe △UBT values during the 4week treatment period and the 2week followup period were not signifificantly different between the treatment group and the placebo group indicating that the inhibitive effects on H pylori were comparable between both groups The monocyte count was 577±111 in the treatment group versus 509±112 in the placebo group P=0044 and the basophile count was 055±032 in the treatment group versus 036±023 in the placebo group P=0024 at week 2 of the treatment period both of which reached statistical signifificance The monocyte count was 575±126 in the treatment group and 472±099 in the placebo group at the end of the followup period P=0003There was no signifificant inhibitive effects of the three probiotic strains L acidophilus L rhamnosus and L sporogenes on H pylori Probiotics can not play the same role as antibiotics in the eradication of H pylori the role of probiotics is likely to be important as adjuvant to the triple or quadruple therapy for H pylori especially in resistance cases
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