Authors: C L H Huang
Publish Date: 1988/09/01
Volume: 412, Issue: 4, Pages: 445-447
Abstract
The effect of prior charge transfers on intramembrane charge movements was investigated in voltageclamped frog skeletal muscle fibres 10mV steps betweenfixed prepulse and test voltages were imposed at varying intervals after a 5mV prepulse step made from a previous conditioning level The amount of charge transfer prior to the test step was varied by altering the extent to which the test step intercepted slow qΓ currents elicited in the prepulse The greater the prior charge transfer the more rapid the transients in the subsequent test step In contrast where the prepulse had not reached the threshold of slow currents or at larger depolarizations where the then faster charging currents were not intercepted charge movements induced by the test step had a constant size and form Charging kinetics thus varied with preceding charge transfer consistent with higherorder cooperative Huang 1984 or sequential Almers 1978 schemes for the nonlinear charge
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