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Title of Journal: Pflugers Arch Eur J Physiol

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Abbravation: Pflügers Archiv - European Journal of Physiology

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Springer-Verlag

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1432-2013

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AQP1 mediates water transport in the carotid body

Authors: Ana M MuñozCabello Javier Villadiego Juan J ToledoAral José LópezBarneo Miriam Echevarría
Publish Date: 2010/01/05
Volume: 459, Issue: 5, Pages: 775-783
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Abstract

In this study we explored the presence of aquaporins AQPs a family of membrane water channel proteins in carotid body CB type I chemoreceptor cells The CB is a polymodal chemoreceptor whose major function is to detect changes in arterial O2 tension to elicit hyperventilation during hypoxia The CB has also been proposed to function as a systemic osmoreceptor thus we hypothesized that the presence of AQPs in type I cell membrane may confer higher sensitivity to osmolarity changes and hence accelerate the activation of chemoreceptor cells We detected the expression of AQP1 AQP7 and AQP8 in the CB and confirmed the location of AQP1 in type I cells We have also shown that inhibition of AQP1 expression clearly reduced type I cell swelling after a hyposmotic shock demonstrating that AQP1 has a major contribution in transmembrane water movement in these chemoreceptor cells Interestingly CB AQP1 expression levels change during postnatal development increasing during the first postnatal weeks as the organ matures In conclusion in this study we report the novel observation that AQPs are expressed in the CB We also show that AQP1 mediates water transport across the cell membrane of type I cells supporting the contribution of this protein to the osmoreception function of the CBWe thank Drs Ricardo Pardal Patricia OrtegaSaenz and Rocio Sanchez for their technical help This work was funded by grants from the Ministry of Science and Innovation “Instituto de Salud Carlos III” PI PI060511 and CIBERNED Junta de Andalucía Consejería de Salud exp 0144 and 0192 and Consejería de Innovación Ciencia y Empresa P08CTS03574 and Marcelino Botín Foundation AM MunozCabello was supported by a predoctoral fellowship from the Spanish Ministry of Health J Villadiego is supported by a postdoctoral fellowship of Instituto de Salud Carlos III–Red de Terapia Celular Spanish Ministry of Science and Innovation

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