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Title of Journal: Pflügers Arch — Eur J Physiol

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Abbravation: Pflügers Archiv - European Journal of Physiology

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Springer Berlin Heidelberg

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DOI

10.1016/0022-3913(58)90144-6

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ISSN

1432-2013

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Enhancement of theEmphasis Type="Italic"Shaker/

Authors: Saïd Bendahhou William S Agnew
Publish Date: 1996/10/01
Volume: 432, Issue: 6, Pages: 1091-1093
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Abstract

Voltagegated K+ channels are modulated by extracellular free unsaturated fatty acids Both increases and attenuations of K+ channel activities have been observed We studied the effect of cisunsaturated fatty acids onShaker B Δ6–46 and the endogenous outward rectifier K+ channels expressed in COS cell line using the whole cell recording technique For both K+ channels exogenously applied unsaturated fatty acids dramatically increased the outward K+ currents This enhancement was not mediated by cylooxygenase or epoxygenase P450 enzymes However nordihydroguaiaretic acid a lipoxygenase metabolic pathway blocker did prevent the arachidonic acidinducedShaker current enhancement

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