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Title of Journal: Pflugers Arch Eur J Physiol

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Abbravation: Pflügers Archiv - European Journal of Physiology

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Springer-Verlag

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DOI

10.1007/s10578-008-0106-9

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1432-2013

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Overexpression of inducible 70kDa heat shock prot

Authors: Elen H Miyabara Tabata L Nascimento Débora C Rodrigues Anselmo S Moriscot Wilmer F Davila Younss AitMou Pieter P deTombe Ruben Mestril
Publish Date: 2012/03/06
Volume: 463, Issue: 5, Pages: 733-741
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Abstract

Heat shock proteins play a key regulatory role in cellular defense To investigate the role of the inducible 70kDa heat shock protein HSP70 in skeletal muscle atrophy and subsequent recovery soleus SOL and extensor digitorum longus EDL muscles from overexpressing HSP70 transgenic mice were immobilized for 7 days and subsequently released from immobilization and evaluated after 7 days Histological analysis showed that there was a decrease in crosssectional area of type II myofiber from EDL and types I and II myofiber from SOL muscles at 7day immobilization in both wildtype and HSP70 mice At 7day recovery EDL and SOL myofibers from HSP70 mice but not from wildtype mice recovered their size Muscle tetanic contraction decreased only in SOL muscles from wildtype mice at both 7day immobilization and 7day recovery however it was unaltered in the respective groups from HSP70 mice Although no effect in a fatigue protocol was observed among groups we noticed a better contractile performance of EDL muscles from overexpressing HSP70 groups as compared to their matched wildtype groups The number of NCAM positivesatellite cells reduced after immobilization and recovery in both EDL and SOL muscles from wildtype mice but it was unchanged in the muscles from HSP70 mice These results suggest that HSP70 improves structural and functional recovery of skeletal muscle after disuse atrophy and this effect might be associated with preservation of satellite cell amountThe authors thank Dr Timothy J Koh for great initial advices This study was financially supported by grants from the Fundação de Amparo à Pesquisa do Estado de São Paulo FAPESP Foundation for the Support of Research in the State of São Paulo to EHM as well as from an award by USAMRMC and TATRC contract W81XWH1020119 to RM TLN and DCR received fellowships from FAPESP grant 10/048138 and the Programa Institucional de Bolsas de Iniciação Científica/Conselho Nacional de Desenvolvimento Científico e Tecnológico PIBIC/CNPq Institutional Program of Scientific Initiation Fellowships/The National Council for Scientific and Technological Development grant 136849/20091

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