Authors: Marjeta Tomšič Matić Metka Derganc Branka Wraber Janez Primožič
Publish Date: 2016/10/27
Volume: 440, Issue: 1, Pages: R075-R077
Abstract
The aim of our study was to evaluate the diagnostic accuracy of serial determination of interleukin6 IL6 and soluble receptors of interleukin2 sIL2R in the diagnosis of early infection in the critically ill newborns and compare it with the routinely used Creactive protein CRP Fourtysix critically ill newborns median age 8 h range 196 h treated at the multidisciplinary intensive care unit Division for Paediatric Surgery and Intensive Care University Medical Centre Ljubljana were included in the study Newborns were divided into three groups group I microbiologically confirmed severe infection n = 14 group II suspected but not confirmed infection n = 12 and group III respiratory distress syndrome without laboratory signs of infection Serum concentrations of IL6 sIL2R and CRP were determined on admission and at 12 and 24 h after admission On admission the concentrations of IL6 and sIL2R were significantly higher in group I than in group III but there was no difference between groups I and II On admission area under receiver operating characteristic ROC curve for IL6 was 0756 for IL2R 0821 and for CRP 0799 Repeated determination at 12 h improved diagnostic accuracy for sILR and CRP but not for IL6
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