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Title of Journal: Pflügers Arch Eur J Physiol

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Abbravation: Pflügers Archiv - European Journal of Physiology

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Springer Berlin Heidelberg

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DOI

10.1016/0009-8981(68)90148-4

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1432-2013

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Opioid receptormediated effects of interleukin2

Authors: ChunMei Cao Qiang Xia YingYing Chen Xiong Zhang YueLiang Shen
Publish Date: 2001/10/13
Volume: 443, Issue: 4, Pages: 635-642
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Abstract

Cytokines play significant roles in some cardiovascular disorders but direct myocardial effects of cytokines remain to be elucidated In this study we examined the effects and possible mechanisms of interleukin2 IL2 on contraction and the Ca2+i transient of enzymatically isolated ventricular myocytes with spectrofluorometry and video tracking IL2 25–200 U/ml depressed both the contraction and the Ca2+i transient in a dosedependent manner Pretreatment with the universal opioid receptor antagonist naloxone 10 nM or a specific κ opioid receptor antagonist norbinaltorphimine norBNI 10 nM abolished the inhibitory effect of IL2 on contraction and the Ca2+i transient the specific δopioid receptor antagonist naltrindole 1 µM had no effect The effect of IL2 was also abolished after pretreatment with pertussis toxin PTX 5 mg/l but not by genistein 100 µM Pretreatment with the phospholipase C inhibitor U73122 5 µM significantly inhibited the IL2induced depression of contraction and the Ca2+i transient It is concluded that the effects of IL2 on contraction and the Ca2+i transient of ventricular myocytes are mediated via the cardiac κ opioid receptor and the postreceptor signal transduction pathway includes a PTXsensitive G protein and phospholipase C

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