Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Pflugers Arch Eur J Physiol

Search In Journal Title:

Abbravation: Pflügers Archiv - European Journal of Physiology

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1007/bf00534423

Search In DOI:

ISSN

1432-2013

Search In ISSN:
Search In Title Of Papers:

Piezo1dependent regulation of urinary osmolarity

Authors: Joana Raquel Martins David Penton Rémi Peyronnet Malika Arhatte Céline Moro Nicolas Picard Birgül Kurt Amanda Patel Eric Honoré Sophie Demolombe
Publish Date: 2016/03/29
Volume: 468, Issue: 7, Pages: 1197-1206
PDF Link

Abstract

The collecting duct CD is the final segment of the kidney involved in the fine regulation of osmotic and ionic balance During dehydration arginine vasopressin AVP stimulates the expression and trafficking of aquaporin 2 AQP2 to the apical membrane of CD principal cells thereby allowing water reabsorption from the primary urine Conversely when the secretion of AVP is lowered as for instance upon water ingestion or as a consequence of diabetes insipidus the CD remains water impermeable leading to enhanced diuresis and urine dilution In addition an AVPindependent mechanism of urine dilution is also at play when fasting Piezo1/2 are recently discovered essential components of the nonselective mechanically activated cationic channels Using quantitative PCR analysis and taking advantage of a βgalactosidase reporter mouse we demonstrate that Piezo1 is preferentially expressed in CD principal cells of the inner medulla at the adult stage unlike Piezo2 Remarkably siRNAs knockdown or conditional genetic deletion of Piezo1 specifically in renal cells fully suppresses activity of the stretchactivated nonselective cationic channels SACs Piezo1 in CD cells is dispensable for urine concentration upon dehydration However urinary dilution and decrease in urea concentration following rehydration are both significantly delayed in the absence of Piezo1 Moreover decreases in urine osmolarity and urea concentration associated with fasting are fully impaired upon Piezo1 deletion in CD cells Altogether these findings indicate that Piezo1 is critically required for SAC activity in CD principal cells and is implicated in urinary osmoregulationWe are grateful to the ANR 2008 du gène à la physiopathologie des maladies rares aux maladies communes to the ANR 2011 physiologie physiopathologie santé publique to the Fondation de la recherche médicale to the Fondation de recherche sur l’hypertension artérielle to the Fondation de France to the Association Française contre les Myopathies RP to the Association pour l’information et la recherche sur les maladies rénales génétiques France to the Région Provence Alpes Côte d’Azur to the Société Française d’hypertension artérielle to the Université de Nice Sophia Antipolis and to the CNRS for financial support JRM was a recipient of fellowship attributed by the LefoulonDelalande Fondation We are grateful to Dr Dorien Peters for sharing the KsprCre mice with us and to Dr Jacques Teulon for his help with the electrophysiology of isolated renal tubules


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Evaluation of biomechanical status of dysplastic human hips
  2. Molecular physiology of EAAT anion channels
  3. Initial charge distribution and capacity transients in frog skeletal muscle
  4. How steroid hormones act on the endothelium—insights by atomic force microscopy
  5. Effects of temperature on pacemaker potentials in the mouse small intestine
  6. Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts
  7. High glucose inhibits HCO 3 − and fluid secretion in rat pancreatic ducts
  8. Possibilities for clinical use of prostacyclin in vascular disease
  9. Glutathione peroxidase 1 protects mitochondria against hypoxia/reoxygenation damage in mouse hearts
  10. Enhanced uridine adenosine tetraphosphate-induced contraction in renal artery from type 2 diabetic Goto-Kakizaki rats due to activated cyclooxygenase/thromboxane receptor axis
  11. From taste to touch: sensory signaling in model organisms
  12. Expression and function of K v 7 channels in murine myometrium throughout oestrous cycle
  13. Regulation of voltage-gated sodium current by endogenous Src family kinases in cochlear spiral ganglion neurons in culture
  14. Tumor suppressor gene adenomatous polyposis coli downregulates intestinal transport
  15. Macrophages in vascular inflammation and atherosclerosis
  16. Sex differences in cardiac autonomic regulation and in repolarisation electrocardiography
  17. Endoplasmic reticulum–mitochondria coupling: local Ca 2+ signalling with functional consequences
  18. Intercellular and extracellular mechanotransduction in cardiac myocytes
  19. Overexpression of inducible 70-kDa heat shock protein in mouse improves structural and functional recovery of skeletal muscles from atrophy
  20. Antagonism of stromal cell-derived factor-1α reduces infarct size and improves ventricular function after myocardial infarction
  21. Role of smooth muscle cell mineralocorticoid receptor in vascular tone
  22. Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation
  23. P2X 3 receptor gating near normal body temperature
  24. Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice
  25. Pathophysiology of HCN channels
  26. Dynamic modulation of intracellular glucose imaged in single cells using a FRET-based glucose nanosensor
  27. Allosteric regulation of the P2X4 receptor channel pore dilation
  28. Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress
  29. Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc Min/+ mouse
  30. lnterleukin-6 (IL-6) and soluble receptors for interleukin-2 (slL-2R) in the diagnosis of early severe infection in the critically ill newborns
  31. Regulation of mineral metabolism by lithium
  32. Enhancement of the Shaker B Δ6–46 current by fatty acids depends on the activation of the lipoxygenase metabolic pathway
  33. Contribution of calcium-conducting channels to the transport of zinc ions
  34. Role of bestrophin-1 in store-operated calcium entry in retinal pigment epithelium
  35. A brief history of trp : commentary and personal perspective
  36. Glutamate receptors, neurotoxicity and neurodegeneration
  37. The I Cl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP 2
  38. Localization of the ergtoxin-1 receptors on the voltage sensing domain of hERG K + channel by AFM recognition imaging
  39. Circadian variation in the effects of nitric oxide synthase inhibitors on body temperature, feeding and activity in rats
  40. Regulated acid–base transport in the collecting duct
  41. AQP1 mediates water transport in the carotid body
  42. Closure of multiple types of K + channels is necessary to induce changes in renal vascular resistance in vivo in rats
  43. Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype
  44. Enhanced desensitization followed by unusual resensitization in GABA A receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice
  45. Sensitisation of TRPV4 by PAR 2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase
  46. Opioid receptor-mediated effects of interleukin-2 on the [Ca 2+ ] i transient and contraction in isolated ventricular myocytes of the rat
  47. Kv1 and Kir2 potassium channels are expressed in rat brain endothelial cells
  48. SGK1 activity in Na + absorbing airway epithelial cells monitored by assaying NDRG1-Thr 346/356/366 phosphorylation
  49. Genistein inhibits voltage-gated sodium currents in SCG neurons through protein tyrosine kinase-dependent and kinase-independent mechanisms
  50. An Editor’s farewell!
  51. Effects of glucose, forskolin and tolbutamide on membrane potential and insulin secretion in the insulin-secreting cell line INS-1
  52. Inosine partially mimics the effects of glucose on ionic fluxes, electrical activity, and insulin release in mouse pancreatic B-cells

Search Result: