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Title of Journal: Virus Genes

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Abbravation: Virus Genes

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Springer US

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DOI

10.1007/s11869-016-0401-8

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ISSN

1572-994X

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Isolation of Virus from a SARS Patient and Genome

Authors: Ying Zhu Mo Liu Weiguang Zhao Jianlin Zhang Xue Zhang Ke Wang Chunfang Gu Kailang Wu Yan Li Congyi Zheng Gengfu Xiao Huimin Yan Jiamin Zhang Deyin Guo Po Tien Jianguo Wu
Publish Date: 2005/01/01
Volume: 30, Issue: 1, Pages: 93-102
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Abstract

Severe acute respiratory syndrome SARS caused by SARSassociated coronavirus SARSCoV is a fatal disease Prevention of future outbreaks is essential and requires understanding pathogenesis and evolution of the virus We have isolated a SARSCoV in China and analyzed 47 SARSCoV genomes with the aims to reveal the evolution trends of the virus and provide insights into understanding pathogenesis and SARS epidemic Specimen from a SARS patient was inoculated into cell culture The presence of SARSCoV was determined by RTPCR and confirmed by electron microscopy Virus was isolated followed by the determination of its genome sequences which were then analyzed by comparing with other 46 SARSCoV genomes Genetic mutations with potential implications to pathogenesis and the epidemic were characterized This viral genome consists of 29728 nucleotides with overall organization in agreement with that of published isolates A total of 348 positions were mutated on 47 viral genomes Among them 22 had mutations in more than three genomes Hot spots of nucleotide variations and unique trends of mutations were identified on the viral genomes Mutation rates were different from gene to gene and were correlated well with periodical or geographic characteristics of the epidemic

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  10. Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants
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