Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Virus Genes

Search In Journal Title:

Abbravation: Virus Genes

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1002/hlca.19760590309

Search In DOI:

ISSN

1572-994X

Search In ISSN:
Search In Title Of Papers:

Mutations of two transmembrane cysteines of hemagg

Authors: Shun Xu Jianqiang Zhou Kang Liu Qiliang Liu Chunyi Xue Xiaoming Li Jing Zheng Dongyu Luo Yongchang Cao
Publish Date: 2013/06/08
Volume: 47, Issue: 1, Pages: 20-26
PDF Link

Abstract

Influenza A H3N2 virus caused 1968 Hong Kong influenza pandemic and has since been one of the most prevalent seasonal influenza viruses in global populations representing a credible pandemic candidate in future Previous studies have established that the hemagglutinin HA protein is the predominant antigen and executes receptor binding and membrane fusion Homologous sequence analysis of all HA subtypes of influenza viruses revealed that two cysteine residues 540 and 544 are uniquely present in the transmembrane domain TM of HA proteins from all influenza A H3N2 viruses However the functions of these two cysteines have not been fully studied Here we generated three mutants C540S C544L and 2C/SL to investigate the effects of the two TM cysteines on the biological functions of H3 HA We herein presented evidences that the mutations of one or two of the cysteines did not affect the proper expressions of HA proteins in cells and more importantly all mutant H3 HAs showed decreased thermal stability but increased fusion activity in comparison with wildtype HA Our results taken together demonstrated that the two TM cysteines are important for the biological functions of H3 HA proteins

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Molecular characterization of the glycoprotein genes of H5N1 influenza A viruses isolated in Israel and the Gaza Strip during 2006 outbreaks
  2. ORF43 of maize rayado fino virus is dispensable for systemic infection of maize and transmission by leafhoppers
  3. Sequence and phylogenetic analysis identifies a putative novel gyrovirus 3 genotype in ferret feces
  4. Combination of intratypic and intertypic recombinant events in EV71: a novel evidence for the “triple-recombinant” strains of genotype A viruses in Mainland China from 2008 to 2010
  5. Expression patterns of prion protein gene in differential genotypes sheep: quantification using molecular beacon real-time RT-PCR
  6. Phylogenetic analysis of the VP1 gene of Enterovirus 71 in Guangzhou during the high occurrence period of 2008
  7. A novel finding for enterovirus virulence from the capsid protein VP1 of EV71 circulating in mainland China
  8. Epidemiological investigation of Middle East respiratory syndrome coronavirus in dromedary camel farms linked with human infection in Abu Dhabi Emirate, United Arab Emirates
  9. Comparative genomic sequence analysis of novel Helicoverpa armigera nucleopolyhedrovirus (NPV) isolated from Kenya and three other previously sequenced Helicoverpa spp. NPVs
  10. Genetic comparisons between lentogenic Newcastle disease virus isolated from waterfowl and velogenic variants
  11. Pathogenicity and insect transmission of a begomovirus complex between tomato yellow leaf curl virus and Ageratum yellow vein betasatellite
  12. Determination of the full length sequence of a chicken astrovirus suggests a different replication mechanism
  13. Identification of a new newcastle disease virus isolate from Indonesia represents an ancestral lineage of class II genotype XIII
  14. Sequencing of the Tamus red mosaic virus genome: further evidence that it is a distinct species of the genus Potexvirus
  15. Evolution and adaptation of hemagglutinin gene of human H5N1 influenza virus
  16. Full-length hepatitis B virus sequences from naïve patients with fluctuation of viral load during ADV monotherapy
  17. Vaccine derived bi- and multi-recombinant Sabin strains
  18. Genomic deletions and mutations resulting in the loss of eight genes reduce the in vivo replication capacity of Meleagrid herpesvirus 1
  19. Molecular characterization and phylogenetic analysis of the complete genome of a hepatitis E virus from European swine
  20. Complete nucleotide sequence of a monopartite Begomovirus and associated satellites infecting Carica papaya in Nepal
  21. Complete nucleotide sequence of a monopartite Begomovirus and associated satellites infecting Carica papaya in Nepal
  22. Full-length sequence analysis of four IBDV strains with different pathogenicities
  23. Diversity and prevalence of Brazilian bipartite begomovirus species associated to tomatoes
  24. Genotyping of human bocavirus using a restriction length polymorphism
  25. Identification and RNA segment assignment of six structural proteins of Scylla serrata reovirus
  26. Instability in vitro of a PCV2 infectious clone containing an insertion between ORF1 and ORF2
  27. Genetic characterization of Amazonian bovine papillomavirus reveals the existence of four new putative types
  28. Isolation of Virus from a SARS Patient and Genome-wide Analysis of Genetic Mutations Related to Pathogenesis and Epidemiology from 47 SARS-CoV Isolates
  29. HN gene C-terminal extension of Newcastle disease virus is not the determinant of the enteric tropism
  30. Resistance gene analogs involved in tolerant cassava–geminivirus interaction that shows a recovery phenotype
Search Result: