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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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DOI

10.1002/npcr.30286

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1432-0843

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Efficacy of combination chemotherapy with capecita

Authors: Ju Hyun Shim JoongWon Park Byung Ho Nam Woo Jin Lee ChangMin Kim
Publish Date: 2008/04/25
Volume: 63, Issue: 3, Pages: 459-467
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Abstract

One patient 05 had modified UICC stage II tumors 12 67 had stage III 51 287 had stage IVa and 114 641 had stage IVb The overall response rate was 197 and 450 achieved tumor growth control Tumor response and disease stability were significantly higher in patients with serum αFP  400 ng/mL those with CLIP score ≤ 2 and those with a uninodular intrahepatic tumor or no residual intrahepatic tumor with extrahepatic tumors alone P  005 The median time to progression TTP and median overall survival were 28 months 95 CI 25–31 months and 105 months 95 CI 79–131 months respectively Multivariate analyses showed that a uninodular or no residual intrahepatic tumor hazard ratio 0524 P = 0006 and female gender hazard ratio 0539 P = 0019 were independent predictors affecting TTP Gastrointestinal symptoms were the most common grade 3 and 4 toxicities

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