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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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DOI

10.1007/bf00850462

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1432-0843

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Circulating endothelial cells predict for response

Authors: Satoshi Matsusaka Mitsukuni Suenaga Yuji Mishima Koichi Takagi Yasuhito Terui Nobuyuki Mizunuma Kiyohiko Hatake
Publish Date: 2010/12/18
Volume: 68, Issue: 3, Pages: 763-768
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Abstract

Standardized enumeration of CEC counts is required to minimize variability and allow crossstudies comparisons The purpose of this paper is to identify CEC threshold proposal by CellSearch system for determining response to bevacizumabbased chemotherapy in metastatic colorectal cancerFrom July 2007 to June 2008 33 patients treated with FOLFOX4 plus bevacizumab were enrolled in a prospective study From January 2007 to June 2007 before bevacizumab was approved by the government in Japan 31 patients treated with FOLFOX4 as a control were enrolled CECs of whole blood at the baseline day 4 2 weeks after initiation of chemotherapy were isolated and counted using CellSearch systemThere was no correlation between CEC levels and the outcome in the FOLFOX4 In the bevacizumabbased chemotherapy CEC levels at the baseline were significantly associated with the outcome Patients with 65 or more CECs at the baseline had a shorter median PFS and OS than the median PFS and OS of less than 65 CECs at the baseline in the bevacizumabbased chemotherapy P = 0003 P = 0027 respectively By univariate and multivariate Cox proportionalhazards regression CEC levels cutoff 65 at the baseline indicated the strongest predictor for the outcome to bevacizumabbased chemotherapyThis work was supported by AstraZeneca Research Grant 2007 the Kobayashi Institute for Innovative Cancer Chemotherapy and a GrantinAid for Scientific Research Japan Society for the Promotion of Science grant number 19790963 21591741 17016077 The excellent technical assistances of Sayuri Minowa Harumi Shibata and Mariko Kimura are greatly appreciated

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