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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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DOI

10.1007/s11273-015-9430-6

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1432-0843

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Anticancer effect of Emphasis Type="Italic"E/E

Authors: Yee Soo Chae Jong Gwang Kim Hyun Jun Jung Jung Dug Yang Jin Hyang Jung Sarah E Aiyar Sanghee Kim Hoyong Park
Publish Date: 2010/10/27
Volume: 68, Issue: 2, Pages: 349-358
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Abstract

TMS 23′45′tetramethoxystilbene a stilbene analog derived from rhapontigenin was previously demonstrated to induce apoptosis in hormoneresistant breast cancer cells Therefore this study investigated the anticancer effect of a new stilbene analog HTMS E2hydroxy3′45′trimethoxystilbene and its mechanism in various breast cancer cell linesThe effect of HTMS on cell proliferation of MDAMB231 MCF7 and LTED cells was evaluated using MTT assays Cell apoptosis was detected by FITCannexin V staining and flow cytometry analysis changes in mitochondrial potential were determined by fluorescence microscopy using TMRE staining and the expression of cleaved PARP and release of cytochrome c were assessed by Western blot analysisHTMS significantly decreased the cell viability of various types of breast cancer cells in a dose and timedependent manner characterized by G2/M arrest of the cell cycle and the induction of apoptosis In particular HTMS disturbed the mitochondrial membrane potential causing a release of cytochrome c during apoptosis Furthermore HTMS was superior to TMS in inhibiting cancer cell growth in a pilot comparison study

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