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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer Berlin Heidelberg

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DOI

10.1016/0020-7837(77)90052-8

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ISSN

1432-0843

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CEACAM1 and hollow spheroid formation modulate the

Authors: Naoyuki Yamamoto Shozo Yokoyama Junji Ieda Yasuyuki Mitani Shunsuke Yamaguchi Katsunari Takifuji Tsukasa Hotta Kenji Matsuda Takashi Watanabe John E Shively Hiroki Yamaue
Publish Date: 2014/12/30
Volume: 75, Issue: 2, Pages: 421-430
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Abstract

Carcinoembryonic antigenrelated cell adhesion molecule 1 CEACAM1 reexpressed and promoted hollow spheroid HS formation beyond the invasion front of colorectal cancer The aim of the present study was to clarify whether CEACAM1 cytoplasmic domain isoform balance and HS are associated with resistance to 5fluorouracil 5FUTwodimensional D or 3D culture systems were employed to evaluate the effects of CEACAM1 cytoplasmic isoform balance and HS formation on the chemosensitivity of colorectal cancer cells to 5FU The risk factors for postoperative recurrence were calculated based on the presence of HS and various clinicopathological characteristics in 82 patients with Stage III colorectal cancer who had undergone curative surgery followed by 5FUbased chemotherapyCEACAM14Ltransfected HT29 and CEACAM14L and 4S expressing parental LS174T cells had significantly higher resistance to 5FU in comparison with CEACAM14S or vector controltransfected cells In 3D culture HS formation induced by CEACAM14L induced chemoresistance to 5FU whereas the solid spheres formed in response to CEACAM14S were destroyed by 5FU treatment HS was identified as an independent factor for recurrence of Stage III colorectal cancer after curative resection followed by 5FUbased chemotherapy Kaplan–Meier survival curves demonstrated that patients with HS had lower recurrencefree survival rate

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