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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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1432-0843

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Central nervous system metastases in a cohort of m

Authors: E Montagna G Cancello D D’Agostino R Lauria V Forestieri A Esposito L Silvestro A Accurso S De Placido M De Laurentiis
Publish Date: 2008/04/01
Volume: 63, Issue: 2, Pages: 275-280
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Abstract

We analyzed the incidence of central nervous system CNS metastases in 78 patients with HER2 overexpressing breast cancer treated with trastuzumab between July 2000 and June 2006 at the Oncology Department of University Federico II in Naples We also characterized and compared patients with and without CNS involvementThe median followup was 353 months 95CI 263–44 median overall survival was 56 months 95CIs 46nr 5 patients showed CNS involvement before trastuzumab therapy while 31 developed CNS metastases during trastuzumab treatment The median overall survival after CNS metastases was 254 months 95CIs 152nr patients with CNS lesions showed worse overall survival than patients without CNS lesions 391 vs 75 months p = 0005CNS metastases are common events in patients with metastatic HER2 overexpressing breast cancer treated with trastuzumab the impact on survival is detrimental even if survival after CNS metastases is longer than historical reports Appropriate investigation of the role of CNS imaging screening and the prophylactic treatment strategies for CNS represents a priority research in this setting

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