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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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DOI

10.1016/0308-521X(91)90058-I

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1432-0843

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A phase II study of gemcitabine and oxaliplatin O

Authors: Atul Sharma Bidhu Mohanti Vinod Raina Nootan Shukla Sujoy Pal Amit Dwary Surya Deo Peush Sahni Pramod Garg Sanjay Thulkar Siddhartha DattaGupta Goura Rath
Publish Date: 2009/07/03
Volume: 65, Issue: 3, Pages: 497-
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Abstract

There is a need for effective chemotherapy protocols for gall bladder cancer GBC Gemcitabine has antitumor activity in pancreatic cancer Oxaliplatin is effective in GI cancers Based on evidence of synergy between these two we designed this study to evaluate efficacy of this combination in unresectable GBCCR 3 62 PR 7 15 SD 17 354 and PD 18 One had complete pathological response Median OS and PFS were 75 and 3 months respectively OS in responders was 105 versus 4 months in nonresponders p  00000 Eleven patients 23 survived for a year or more There was no toxic death and grade III/IV toxicity seen in 10 22 patients diarrhea 3 vomiting 2 neutropenia and thrombocytopenia 5 patients

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