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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer Berlin Heidelberg

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DOI

10.1007/bf03315560

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1432-0843

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Posttreatment with cotinine improved memory and d

Authors: Alexandre Iarkov Doreen Appunn Valentina Echeverria
Publish Date: 2016/10/05
Volume: 78, Issue: 5, Pages: 1033-1039
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Abstract

Most cancer patients treated with systemic adjuvant chemotherapy endure longlasting side effects including decrease in concentration forgetfulness and slower thinking which are globally termed “chemobrain” Cotinine the main derivative of nicotine improved visual and spatial working memory and decreased depressivelike behavior in an animal model of chemotherapyinduced cognitive impairmentIn this study we investigated the effect of cotinine on weight gain locomotor activity cognitive abilities and depressivelike behavior in rats treated with the chemotherapy mix cyclophosphamide methotrexate and 5fluorouracil Locomotor activity and depressivelike behavior were assessed using the rotarod and Porsolt’s tests respectively Changes in cognitive abilities were determined using the novel place recognition test

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