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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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DOI

10.1002/asia.201000358

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1432-0843

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Efficacy and safety of ixabepilone in taxaneresis

Authors: Kenjiro Aogi Yoshiaki Rai Yoshinori Ito Norikazu Masuda Junichiro Watanabe Jun Horiguchi Takuto Tokudome Shigemitsu Takashima
Publish Date: 2013/03/28
Volume: 71, Issue: 6, Pages: 1427-1433
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Abstract

Anthracycline and taxane resistance is a key issue in the treatment of metastatic breast cancer MBC particularly in Asian patients who often present with advanced disease The objective of this study was to investigate the efficacy and safety of ixabepilone monotherapy in Japanese patients with taxaneresistant MBC previously treated with anthracyclineJapanese patients with taxaneresistant MBC previously treated with anthracycline were treated with 40 mg/m2 ixabepilone every 3 weeks Primary endpoint was overall response rate Secondary endpoints included duration of response time to progression TTP and safetyFiftytwo patients were treated with ixabepilone Overall response rate was 115  95  confidence interval 44–234 stable disease rate was 385  duration of response was 36 months range 24−53 months and TTP was 28 months range 07–81 months The most frequent grade 3/4 toxicities were neutropenia 827  leukopenia 75  myalgia 192  and peripheral neuropathy 192 The Ixabepilone Breast Cancer Study Group consists of the following centers Department of Breast Surgery Hakuaikai Sagara Hospital Department of Breast Oncology National Hospital Organization Shikoku Cancer Center Department of Breast and Endocrine Surgery 2nd Surg Gunma University Hospital Department of Medical Oncology Cancer Institute Ariake Hospital Department of Surgery Breast Oncology National Hospital Organization Osaka National Hospital Department of Women’s Health Shizuoka Cancer Center Department of Surgery Niigata Cancer Center Hospital Department of Endocrinology Saitama Cancer Center Department of Breast Oncology Aichi Cancer Center Hospital Department of Drug Therapy Tochigi Cancer Center Department of Clinical Oncology Saitama Medical University Hospital Department of Chemotherapy National Cancer Center Hospital East Breast and Medical Oncology Division National Cancer Center Hospital Department of Medical Oncology Kinki University School of Medicine Nara Hospital Department of Breast and Thyroid Surgery Kawasaki Medical School Hospital Department of Surgery Tokyo Metropolitan Komagome Hospital Breast and Endocrine Surgery Tokai University Hospital Department of Breast Surgical Oncology St Luke’s International Hospital and Department of Breast Oncology National Hospital Organization Kyushu Cancer Center The authors take full responsibility for the content of this publication and confirm that it reflects their views and scientific expertise This study was supported by a grant from BristolMyers KK


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