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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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DOI

10.1002/ijch.197600010

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1432-0843

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The effect of thalidomide on the pharmacokinetics

Authors: Jacqueline Ramírez Kehua Wu Linda Janisch Theodore Karrison Larry K House Federico Innocenti Ezra E W Cohen Mark J Ratain
Publish Date: 2011/08/23
Volume: 68, Issue: 6, Pages: 1629-1632
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Abstract

Irinotecan and thalidomide are commonly administered antineoplastic drugs Combination treatment may potentiate their antitumor effect and protect against irinotecan’s intestinal toxicity We investigated whether thalidomide can modulate the pharmacokinetics of irinotecan and metabolitesThe study employed a crossover design in which advanced solid tumor patients were randomized to two arms and treated with irinotecan 350 mg/m2 intravenously IV every 3 weeks and thalidomide orally po 400 mg daily Pharmacokinetic data when irinotecan was administered as a single agent in each arm were compared to data when the two study agents were coadministered using paired t tests Eighty percent and 90 confidence intervals for the true difference were also calculated

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