Authors: Tomoyo Oguri Tomoya Shimokata Megumi Inada Isao Ito Yuichi Ando Yasutsuna Sasaki Yoshinori Hasegawa
Publish Date: 2010/06/19
Volume: 66, Issue: 4, Pages: 813-817
Abstract
We treated two patients who were undergoing hemodialysis and received carboplatinbased chemotherapy to treat nonsmallcell lung cancer or ovarian cancer The dose of carboplatin was calculated by the Calvert formula Glomerular filtration rate was considered to be 0 and the target area under the plasma concentration versus time curve AUC was 4 carboplatin dose 100 mg for patient 1 and 5 125 mg for patient 2 Carboplatin was administered as a 1h intravenous infusion on day 1 Hemodialysis was performed for 3 or 4 h starting 24 h after the infusion of carboplatin had begun Heparinized blood samples were collected during the first cycle of chemotherapyThe AUCs in patients 1 and 2 were 47 and 61 mg/ml min which were about 20 higher than the target values 4 and 5 mg/ml min respectively In the absence of hemodialysis the hypothetical AUCs were 62 and 76 mg/ml min respectively The predialysis body clearances of carboplatin were 161 and 165 ml/min with elimination halflives of 175 and 138 h respectivelyBy performing hemodialysis 24 h after the start of chemotherapy we obtained reproducible and robust AUC data Use of the Calvert formula allowed carboplatinbased chemotherapy to be performed safely Our results suggest that the nonrenal clearance of carboplatin is lower in Japanese patients than in nonAsian patients
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