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Title of Journal: Cancer Chemother Pharmacol

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Abbravation: Cancer Chemotherapy and Pharmacology

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Springer-Verlag

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DOI

10.1007/bf00194949

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1432-0843

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Influence of the etiology of liver cirrhosis on th

Authors: Masahiro Kanayama Hidenari Nagai Yasukiyo Sumino
Publish Date: 2008/11/01
Volume: 64, Issue: 1, Pages: 109-
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Abstract

We have previously reported that intraarterial chemotherapy prolongs the survival of patients with advanced HCC aHCC however whether the response to intraarterial chemotherapy depends on the etiology of underlying liver cirrhosis LC is still unknownA total of 53 adult Japanese LC patients 46 men and 7 women with aHCC were treated with combined intraarterial chemotherapy between 2002 and 2007 at our hospital All of the patients had a Japan Integrated Staging JIS score of 3 or 4 Their tumors were inoperable according to computed tomography findings Combined intraarterial chemotherapy was administered via the proper hepatic artery every 5 days for 4 weeks and the chemotherapy regimen was continued for as long as possibleThere were 15 patients with HBV infection BLC group 29 patients with HCV infection CLC group and nine patients with alcoholic cirrhosis ALC group The percentage of patients with a complete or partial response after 4 weeks of chemotherapy was 0 in the BLC group versus 310 in the CLC group and 444 in the ALC group The survival of the ALC and CLC groups was significantly longer than that of the BLC group with the median survival time being 688 368 and 211 days respectively

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