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Title of Journal: Heart Vessels

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Abbravation: Heart and Vessels

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Springer Japan

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DOI

10.1007/bf02344754

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1615-2573

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Sudden death due to aortic rupture in acromegaly

Authors: Pietro Maffei Carla Menegazzo Mauro Michelotto Roberto Salmaso Chiara Martini Eugenio De Carlo Marta Carli Martina Barban Ambrogio Fassina Roberto Vettor Nicola Sicolo
Publish Date: 2008/03/05
Volume: 23, Issue: 1, Pages: 71-74
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Abstract

Acromegaly when left untreated is associated with premature mortality which is chiefly related to cardiovascular complications We report on a 50yearold acromegalic woman resistant to therapy who died suddenly because of thoracic aortic rupture and massive bleeding into the left pleural space The postmortem examination disclosed nearby the point of rupture a pulmonary abscess as well as extensive intrinsic alteration of arteries originating from the aortic arch and aorta itself which featured microscopic cystic medial necrosis We discussed how these aspects could be related to longterm exposition to growth hormone excess In particular this case gives further evidence of vascular system frailty in acromegaly

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