Authors: Michael Sponder Monika FritzerSzekeres Rodrig Marculescu Brigitte Litschauer Jeanette StrametzJuranek
Publish Date: 2015/12/11
Volume: 31, Issue: 10, Pages: 1603-1608
Abstract
The balance between the angiostatic factor endostatin ES and angiogenic factor osteopontin OPN is essential in physiological and pathological angiogenesis Several circumstances might influence this equilibrium and are of distinct interest when investigating mechanisms in coronary artery disease CAD The present explorative crosssectional study was to investigate the influence of physical inactivity on ES and OPN levels in 181 male and 71 female patients with angiographycally verified CAD Anamnestic and laboratory data were collected ES was measured in serum and OPN in plasma by ELISA Univariate analysis of variance was used to test for the influence of physical activity on ES and OPN levels and age BMI sex and diabetes status were included as covariates ES and OPN intercorrelated significantly r = 042 p 0001 ES and OPN decreased significantly in response to increasing activity level of patients suffering CAD F = 55 p 0001 and F = 36 p 001 resp This study is the first to show a linear decrease in ES and OPN levels in CAD patients depending on the degree of physical activity undergone Lower levels of ES and OPN in physically active patients might be a sign of increased angiogenesis and decreased inflammation and calcifying activity and therefore contribute to the understanding of the damaging effect of physical inactivity in cardiovascular disease
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