Authors: Qiang Zhao TongGuo Wu Yi Lin Biao Li JingYun Luo LeXin Wang
Publish Date: 2010/03/26
Volume: 25, Issue: 2, Pages: 97-103
Abstract
This study was designed to investigate the effect of lowdose nesiritide on renal function and major cardiac events in patients with acute decompensated heart failure following acute myocardial infarction Sixty patients were randomized into nesiritide loading dose 05 μg/kg maintenance dose 00075 μg/kg/min and nitroprusside groups Compared with the nitroprusside group the nesiritide group had a greater heart rate reduction P 005 higher 24 h urine volume P 0001 and more significant alleviation in dyspnea P 0001 The prevalence of hypotension in the nesiritide group was lower than in the nitroprusside group 74 vs 285 P 005 The nesiritide group had a greater reduction in serum noradrenaline angiotensin II aldosterone endothelin and Nterminal prohormone brain natriuretic peptide all P 001 The mean serum creatinine in the nesiritide group was reduced 1094 ± 266 vs 1028 ± 216 μmol/l P 001 whereas it remained unchanged in the nitroprusside group 1068 ± 20 vs 1060 ± 192 μmol/l P 005 The rehospitalization or mortality rate was similar between the two groups 3 months after the therapy P 005 We conclude that lowdose nesiritide is more effective in suppressing the activation of the sympathetic and reninangiotensin systems It also improves the clinical symptoms and enhances renal function but its effect on hospital readmission or mortality rate needs further investigation
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