Authors: Diana J Mihalcea Maria Florescu Berenice M C Suran Oana A Enescu Raluca I Mincu Stefania Magda Natalia Patrascu Dragos Vinereanu
Publish Date: 2015/01/30
Volume: 31, Issue: 4, Pages: 568-577
Abstract
Arterial stiffness estimated by pulse wave velocity PWV is an independent predictor of cardiovascular morbidity and mortality Although recommended by the current guidelines clinical applicability of this parameter is difficult due to differences between the various techniques used to measure it and to biological variability Our aim was to compare PWV assessed by 3 different commercially available systems 100 subjects 51 ± 16 years 45 men were evaluated using the 3 methods an oscillometric technique Arteriograph PWVA a piezoelectric method Complior PWVC and an highresolution ultrasound technique implemented with an Echotracking system Aloka PWVE Conventional biological markers were measured Correlations of PWV measured by the 3 methods were poor r = 039 r = 039 and r = 031 for PWVA vs PWVC PWVA vs PWVE and PWVC vs PWVE respectively all p 005 By Bland–Altman analysis mean difference ±SD of PWVA vs PWVC was −19 ± 20 m/s of PWVA vs PWVE −36 ± 19 m/s and of PWVC vs PWVE −27 ± 19 m/s with a wide coefficient of variation 223 257 and 257 respectively As expected PWVA PWVC and PWVE correlated with other arterial stiffness parameters such as intimamedia thickness r = 022 r = 022 and r = 036 respectively E p r = 037 r = 026 and r = 094 respectively and augmentation index measured by Arteriograph method r = 066 r = 035 and r = 026 respectively all p 005 Assessment of PWV is markedly dependent on the technique used to measure it related to various methods for measuring traveled distance of the arterial wave Our results suggest the urgent need to establish reference values of PWV for each of these techniques separately to be used in routine clinical practiceThis work was partly supported by a grant of the Romanian National Authority for Scientific Research CNCSIS—UEFISCDI project number PNIIIDPCE201130791 112/27oct2011 http//wwwclinicaltrialsorg NCT4192910 and partly supported by the Sectorial Operational Program Human Resources Development SOPHRD financed by the European Social Fund and the Romanian Government under the contract number POSDRU 141531
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